Denosumab Treats-
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Denosumab is primarily used to treat osteoporosis, a condition characterized by reduced bone density, resulting in weaker and more fragile bones. It is prescribed to:
Denosumab acts to strengthen bones and minimize the risk of fractures in these different clinical scenarios. However, Denosis 60/1ml Injection is not suitable for individuals with hypocalcemia (low blood calcium levels) or those with dental problems. Pregnant or breastfeeding women should consult their doctors before using this medication. It is not intended for children and adolescents under 18 years of age.
Interaction with alcohol is unknown.
Denosis 60/1ml Injection is not recommended during pregnancy. If pregnancy occurs during treatment or within 5 months after stopping it, consult your doctor.
It is unclear whether Denosis 60/1ml Injection is excreted in human breast milk. Your doctor will help you decide whether to discontinue breastfeeding or discontinue the treatment, considering the benefits to both the mother and the baby.
Denosis 60/1ml Injection has minimal impact on the ability to drive and operate machinery.
Caution is advised when using Denosis 60/1ml Injection in patients with severe kidney problems, kidney failure, or those who have undergone dialysis. Consult your doctor before using it.
Consult your doctor if you have a liver impairment or any concerns regarding this.
Osteoporosis, bone loss, giant cell tumor of the bone, high calcium levels.
Denosis 60/1ml Injection effectively prevents bone resorption by binding tightly to RANKL, a protein that plays a key role in bone breakdown. This interaction inhibits the formation, function, and survival of osteoclasts, which are responsible for absorbing and removing bone. As a result, bone resorption is reduced.
is a bone disease characterized by the weakening and thinning of bones, leading to a decrease in bone density. As bone density decreases, bones become fragile and are more susceptible to fractures. Postmenopausal women are at a higher risk of developing osteoporosis because the ovaries stop producing estrogen, a hormone crucial for maintaining bone health, after menopause. As a result, bone loss occurs, rendering bones weak and prone to fractures. Although osteoporosis is more commonly associated with women, it can also affect men due to aging or low levels of testosterone. Common signs and symptoms of osteoporosis include back pain resulting from fractured or collapsed vertebrae, a gradual loss of height over time, a stooped posture, and bones that break more easily than expected.
Adult Dose:
Elderly: No dosage adjustment is required based on available safety and efficacy data in the elderly.
Hepatic Impairment: The safety and efficacy have not been studied in patients with hepatic impairment.
Renal Dose:
Administration:
Denosumab should be administered subcutaneously (SC) in the upper arm, upper thigh, or abdomen. It should not be given intradermally, intramuscularly, or intravenously. Avoid vigorous shaking of the vial or syringe.
Inform your doctor if you have hypocalcemia (low levels of calcium in the blood) or immunosuppression.
Clinically significant hypersensitivity to denosumab or to any of the components.
Contraception:
Lactation:
Denosumab should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
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